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<article xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" article-type="research-article" dtd-version="1.0" xml:lang="en">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">IJME</journal-id>
      <journal-id journal-id-type="nlm-ta">Int J Med Educ</journal-id>
      <journal-title-group>
        <journal-title>International Journal of Medical Education</journal-title>
        <abbrev-journal-title abbrev-type="pubmed">Int J Med Educ</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="epub">2042-6372</issn>
      <publisher>
        <publisher-name>IJME</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">12-222232</article-id>
      <article-id pub-id-type="doi">10.5116/ijme.615c.2cfa</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Original research</subject>
          <subj-group>
            <subject>Osteopathic medicine</subject>
          </subj-group>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Attitudes toward osteopathic medicine scale: development and psychometrics</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author" corresp="yes">
          <name>
            <surname>Hojat</surname>
            <given-names>Mohammadreza</given-names>
          </name>
          <xref ref-type="aff" rid="aff1">
            <sup>1</sup>
          </xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>DeSantis</surname>
            <given-names>Jennifer</given-names>
          </name>
          <xref ref-type="aff" rid="aff1">
            <sup>1</sup>
          </xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Cain</surname>
            <given-names>Robert A.</given-names>
          </name>
          <xref ref-type="aff" rid="aff2">
            <sup>2</sup>
          </xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Speicher</surname>
            <given-names>Mark R.</given-names>
          </name>
          <xref ref-type="aff" rid="aff2">
            <sup>2</sup>
          </xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Bragan</surname>
            <given-names>Lynn</given-names>
          </name>
          <xref ref-type="aff" rid="aff2">
            <sup>2</sup>
          </xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Calabrese</surname>
            <given-names>Leonard H.</given-names>
          </name>
          <xref ref-type="aff" rid="aff3">
            <sup>3</sup>
          </xref>
        </contrib>
        <aff id="aff1"><label>1</label>Asano-Gonnella Center for Research in Medical Education and Health Care, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania, USA</aff>
        <aff id="aff2"><label>2</label>American Association of Colleges of Osteopathic Medicine, Bethesda, Maryland, USA</aff>
        <aff id="aff3"><label>3</label>Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio, USA</aff>
      </contrib-group>
      <author-notes>
        <corresp id="cor1">Correspondence: Mohammadreza Hojat, Asano-Gonnella Center for Research in Medical Education and Health Care, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania, USA. Email: <email xlink:href="Mohammadreza.Hojat@Jefferson.edu">Mohammadreza.Hojat@Jefferson.edu</email></corresp>
      </author-notes>
      <pub-date pub-type="epub">
        <day>19</day>
        <month>11</month>
        <year>2021</year>
      </pub-date>
      <pub-date pub-type="collection">
        <year>2021</year>
      </pub-date>
      <volume>12</volume>
      <fpage>222</fpage>
      <lpage>232</lpage>
      <history>
        <date date-type="accepted">
          <day>05</day>
          <month>10</month>
          <year>2021</year>
        </date>
        <date date-type="received">
          <day>10</day>
          <month>04</month>
          <year>2021</year>
        </date>
      </history>
      <permissions>
        <copyright-statement>Copyright: &#xA9; 2021 Mohammadreza Hojat et al.</copyright-statement>
        <copyright-year>2021</copyright-year>
        <license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/3.0">
          <license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use of work provided the original work is properly cited. <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/3.0/">http://creativecommons.org/licenses/by/3.0/</ext-link></license-p>
        </license>
      </permissions>
      <abstract>
		  
<sec><title>Objective</title>	  
<p>To develop a valid and reliable instrument
for measuring attitudes toward osteopathic medicine.</p>

</sec><sec><title>Methods</title>
<p>Participants included 5,669 first-year
students from 33 U.S. colleges of osteopathic medicine, who completed an online
survey at the beginning of the 2019-2020 academic year. Using data from the
nationwide Project in Osteopathic Medical Education and Empathy, we developed a
13-item instrument: Attitudes Toward Osteopathic Medicine Scale (ATOMS) and
demonstrated the validity and reliability of its scores. The social
desirability response bias was controlled in statistical analyses.

</p></sec><sec><title>Results</title>
<p>The corrected item-total score correlations
were all positive and statistically significant, and the effect sizes of item
discrimination indices were large. Cronbach&#x2019;s coefficient alpha reliability was
0.83. Construct validity, corroborating face and content validity of the ATOMS,
was supported by three components, emerged from factor analysis: &#x201C;Perspectives
on Osteopathic Medicine,&#x201D; &#x201C;Osteopathic Diagnosis and Treatment,&#x201D; and
&#x201C;Holistic-Integrative Care.&#x201D; Correlations between ATOMS scores and scores of
cognitive empathy, emotional empathy; orientation toward interprofessional
collaboration; lifelong learning; and burnout were statistically significant in
the expected direction, providing validity evidence for the ATOMS. Using the
method of contrasted groups, significant differences in the ATOMS scores were
found by gender, ethnicity, academic background, and career interest in the
expected direction, supporting the validity of the ATOMS scores. National norms
were developed to assess individual scores alongside national percentile ranks.

</p></sec><sec><title>Conclusions</title>
<p>The ATOMS, developed in a nationwide study,
supported by strong psychometric evidence for measuring orientation toward
osteopathic medicine, has implications for the assessment of osteopathic
medical education, patient outcomes, and admission decisions.</p></sec></abstract>
      <kwd-group kwd-group-type="author">
        <kwd>Osteopathic medicine</kwd>
        <kwd>attitudes</kwd>
        <kwd>psychometric</kwd>
        <kwd>empathy</kwd>
        <kwd>burnout</kwd>
        <kwd>lifelong learning</kwd>
        <kwd>interprofessional collaboration</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="intro"><title>Introduction</title>

<p>Diagnosis and treatment of illness in the context of holistic care was recognized in 1874 by Andrew Taylor Still, MD, who called his view of medical care &#x201C;osteopathy&#x201D; and founded the first osteopathic medical school in 1892 in Kirksville, Missouri (currently A.T. Still University-Kirksville College of Osteopathic Medicine). The core tenets of osteopathic medicine specify that a human is a unit of the physical, mental, and social/spiritual; that the body is capable of self-regulation; and that holistic treatment should be based upon an understanding of body unity, self-regulation, and interrelationships of structure and function.<xref ref-type="bibr" rid="r1"><sup>1</sup></xref><sup>,</sup><xref ref-type="bibr" rid="r2"><sup>2</sup></xref></p>
<p>Fundamental osteopathic medical competencies include the application of osteopathic manual diagnosis and treatment; the ability to work effectively with other health care professionals as members or leaders of an interprofessional collaborative team; and demonstration of humanistic behavior such as empathy, altruism, compassion, respect, integrity, honesty, and trustworthiness.<xref ref-type="bibr" rid="r3"><sup>3</sup></xref> While osteopathic and allopathic medical education systems currently share most of the aforementioned features in educating physicians-in-training, osteopathic medicine emphasizes manipulative diagnosis and treatment and holistic care.</p>
<p>Attitudes toward specific features and tenets of osteopathic medicine contribute to the career decisions of applicants and to the practice of medicine by graduates of osteopathic medical schools. Also, the measurement of such attitudes with a psychometrically sound instrument would be crucial for the assessment of osteopathic medical, educational outcomes. However, while reviewing the relevant literature, we noticed a limitation in empirical research in identifying core components of the attitudes toward osteopathic medicine. There are a few instruments intended to measure attitudes, orientation, and beliefs toward aspects of osteopathic medicine, such as osteopathic principles,<xref ref-type="bibr" rid="r4"><sup>4</sup></xref> osteopathic manipulative treatment, osteopathic philosophy,<xref ref-type="bibr" rid="r5"><sup>5</sup></xref><sup>-</sup><xref ref-type="bibr" rid="r8"><sup>8</sup></xref> and osteopathic education.<xref ref-type="bibr" rid="r9"><sup>9</sup></xref> However, these instruments have not been supported by strong psychometric, especially validity evidence. Study participants were often accessible samples from a single institution and insufficient in size.</p>
<p>There was a need for a valid and reliable instrument, developed without suffering from the aforementioned limitations, for measuring attitudes toward osteopathic medicine. In response to this need, we designed this study to develop a psychometrically sound instrument for measuring empirically derived aspects of osteopathic medicine, with potential implications for the assessments of osteopathic medical education outcomes and clinical outcomes of osteopathic care, and to monitor changes as physicians-in-training progress through medical school and postgraduate medical education training. Also, our intention from the onset of the study was to use nationwide data to provide a national norm table for osteopathic medical students to assess their scores on the instrument against the national norm, and possibly use each osteopathic medical school applicant&#x2019;s converted national percentile rank as a supplementary measure for admission decisions.</p>
<sec><title>The nationwide project</title>
<p>This study is part of the landmark nationwide Project in Osteopathic Medical Education and Empathy (POMEE), a two-phased project sponsored by the American Association of Colleges of Osteopathic Medicine and cosponsored by the American Osteopathic Association, in collaboration with the Cleveland Clinic and Sidney Kimmel Medical College at Thomas Jefferson University. Phase I, a 2-year cross-sectional study completed in 2018, laid the foundation for Phase II, a 5-year longitudinal study of changes in empathy and other personal qualities, including attitudes toward osteopathic medicine as students progress through medical school. Data for this article were retrieved from the database of POMEE-Phase II.</p>
</sec></sec>
    <sec sec-type="methods"><title>Methods</title>
<sec><title>Research design and study cohort</title>
<p>Participants in this survey research included 5,669 first-year matriculants to 33 of 36 (92%) of U.S. colleges of osteopathic medicine in the 2019-2020 academic year who voluntarily participated in the study.</p>
<p>The research team at Jefferson obtained exempt status approval for the project from Thomas Jefferson University Institutional Review Board (IRB); all other participating colleges also received IRB approval from their college.</p>
</sec>
		
<sec><title>Study survey</title>
<p>The study survey included questions regarding participants&#x2019; demographics, undergraduate major, and career interest, plus the following instruments:</p>
<sec><title>Attitudes Toward Osteopathic Medicine Scale</title>
<p>We developed a new instrument: Attitudes Toward Osteopathic Medicine Scale (ATOMS); seven items of this instrument were adapted (with author permission) from a 29-item Integrative Medicine Attitudes Questionnaire;<xref ref-type="bibr" rid="r10"><sup>10</sup></xref> six items were developed by two of this study&#x2019;s authors (MH and LHC) for another study with osteopathic medical students.<xref ref-type="bibr" rid="r11"><sup>11</sup></xref> Permission to use selected items from the Integrative Medicine Attitudes Questionnaire was obtained from the author of the questionnaire. Items were answered on a 7-point Likert scale (1=Absolutely Disagree, 7=Absolutely Agree).</p>
</sec><sec><title>Cognitive (Clinical) Empathy</title>
<p>We measured clinical empathy using the Jefferson Scale of Empathy (JSE, 20-item, medical student version), a broadly used and validated instrument for measuring clinical empathy in the context of patient care, developed based on the conceptualization of empathy as a predominantly cognitive attribute. Evidence from medical school student samples in the U.S. and abroad supports psychometrics of the JSE<xref ref-type="bibr" rid="r12"><sup>12</sup></xref> &#xA0;and specifically in first-year matriculants of osteopathic medical schools (POMEE Phase I).<xref ref-type="bibr" rid="r13"><sup>13</sup></xref> Moreover, the JSE has been recognized as the most studied instrument in medical education research,<xref ref-type="bibr" rid="r14"><sup>14</sup></xref> and the most frequently used instrument for measuring clinical empathy in medical education.<xref ref-type="bibr" rid="r15"><sup>15</sup></xref></p>
</sec><sec><title>Emotional Empathy</title>
<p>Cognitive and emotional empathy could have different consequences in the context of patient care.<xref ref-type="bibr" rid="r12"><sup>12</sup></xref> Because of its affective nature, excess emotional empathy (synonymous with sympathy) can be detrimental to patient care.<xref ref-type="bibr" rid="r12"><sup>12</sup></xref> We included emotional empathy to differentiate the effects of cognitive empathy (understanding patient&#x2019;s suffering) from emotional empathy (e.g., feeling patient&#x2019;s pain) on outcome measures. We selected the following two scales from the Interpersonal Reactivity Index (IRI): &#x201C;empathic concern&#x201D; and &#x201C;personal distress.&#x201D;<xref ref-type="bibr" rid="r16"><sup>16</sup></xref><sup>-</sup><xref ref-type="bibr" rid="r17"><sup>17</sup></xref> Each scale contains seven items. The total score of these two scales was considered as an indicator of emotional empathy.<xref ref-type="bibr" rid="r16"><sup>16</sup></xref><sup>-</sup><xref ref-type="bibr" rid="r18"><sup>18</sup></xref> Moderate correlations between scores of the IRI scales and the JSE have been reported in medical students.<xref ref-type="bibr" rid="r19"><sup>19</sup></xref> Permission to use this instrument in this study was obtained from the author of the IRI.</p>
</sec><sec><title>Attitudes Toward Interprofessional Collaboration</title>
<p>We used the Jefferson Scale of Attitudes Toward Interprofessional Collaboration (JeffSATIC), a 20-item validated instrument measuring orientation toward interprofessional collaboration and teamwork in health professions students and practitioners. Evidence supporting measurement properties of this instrument has been reported in a multi-institutional and multi-national study of health professions students.<xref ref-type="bibr" rid="r20"><sup>20</sup></xref></p>
</sec><sec><title>Attitudes Toward Lifelong Learning</title>
<p>We used the Jefferson Scale of Attitudes Toward Physician Lifelong Learning (JSPLL), a 14-item instrument adapted from the Jefferson Scale of Physician Lifelong Learning,<xref ref-type="bibr" rid="r21"><sup>21</sup></xref> for administration to medical students.<xref ref-type="bibr" rid="r22"><sup>22</sup></xref> Evidence has been reported supporting measurement properties of the JSPLL in physicians<xref ref-type="bibr" rid="r21"><sup>21</sup></xref> and medical students.<xref ref-type="bibr" rid="r22"><sup>22</sup></xref></p>
</sec><sec><title>Burnout Measure</title>
<p>We used the Shirom-Melamed Burnout Measure (BM),<xref ref-type="bibr" rid="r23"><sup>23</sup></xref><sup>-</sup><xref ref-type="bibr" rid="r25"><sup>25</sup></xref> a 14-item instrument to measure overall burnout experiences. The instrument has been used in a multi-institutional study with medical students.<xref ref-type="bibr" rid="r26"><sup>26</sup></xref> Permission to use this instrument in this study was obtained from its author.</p>
</sec><sec><title>&#x201C;Good Impression&#x201D; Response Bias</title>
<p>Respondents to self-reported personality tests can manipulate their answers to produce disingenuous responses, known as the &#x201C;social desirability response set.&#x201D; We used the &#x201C;Infrequency&#x201D; Scale of the Zuckerman-Kuhlman Personality Questionnaire (ZKPQ)<xref ref-type="bibr" rid="r27"><sup>27</sup></xref> to control for the effect of the social desirability response bias. This 10-item scale identifies subjects with invalid records due to an exaggerated &#x201C;good impression&#x201D; response bias. Scores higher than three on this scale indicates questionable validity of the respondent record.<xref ref-type="bibr" rid="r27"><sup>27</sup></xref> This scale was previously used with medical students to detect and control for the tendency to make &#x201C;good impression&#x201D; responses,<xref ref-type="bibr" rid="r12"><sup>12</sup></xref><sup>,</sup><xref ref-type="bibr" rid="r28"><sup>28</sup></xref> and in POMEE-Phase I.<xref ref-type="bibr" rid="r13"><sup>13</sup></xref><sup>,</sup><xref ref-type="bibr" rid="r29"><sup>29</sup></xref><sup>-</sup><xref ref-type="bibr" rid="r31"><sup>31</sup></xref></p>
</sec></sec><sec><title>Procedures</title>
<p>Two pilot studies were undertaken with volunteer osteopathic medical students and medical education researchers to improve the clarity and comprehensiveness of the study survey, to detect any possible technical issues in its online administration (pilot study 1), and to test it when using desktop, laptop, and mobile devices (pilot study 2).</p>
<p>One or two research coordinators from each participating college or campus were selected to serve as liaisons between students, the colleges, AACOM, and the research team at Jefferson. Research coordinators and the AACOM research team arranged with college administrators to schedule an appropriate time for online group administration of the study survey at local campuses and helped to maximize response rates.</p>
<p>Participants were informed that their email addresses would be used as a unique identifier to track, match, and merge data from multiple survey administrations. Before the administration of the survey, students received an email signed by the dean of their medical school that included a brief message about the importance of the project and its goals. Subsequently, students received another email message, encouraging them to participate as an &#x201C;indispensable&#x201D; stakeholder of this landmark project, signed by Robert Cain, DO, president and CEO of the AACOM, and Leonard Calabrese, DO, of the Cleveland Clinic (principal co-investigators of the project).</p>
<p>We administered the initial web-based study survey at the beginning of the 2019-2020 academic year prior to the start of medical school classes. Our study survey accompanied the AACOM matriculating student survey. Respondents were given the option to voluntarily complete the accompanying study survey. They could also voluntarily enter their email addresses to receive feedback on their empathy scores. Online administration of the study survey was managed by the AACOM research team.</p>
</sec><sec><title>Statistical analyses</title>
<p>We calculated Cronbach&#x2019;s coefficient alpha, and examined corrected item-total score correlations, item discrimination effect sizes, underlying factor structure, and used bivariate correlations (Pearson), multivariate regression analysis, and the method of contrasted-groups to confirm the validity and reliability of the ATOMS, developed in this study. The Statistical Analysis System (SAS for Windows, version 9.4) was used for statistical analyses.</p>
</sec></sec>
    <sec sec-type="results"><title>Results</title>
<p>A total of 5,979 students of 7,781 total first-year matriculants in all U.S. colleges of osteopathic medicine (77%) submitted their online survey. Excluded were incomplete surveys and respondents&#x2019; records with questionable validity (scored&gt;3 on the Infrequency Scale of the ZKPQ). Therefore, the final sample for statistical analyses included 5,669 students; 2,653 self-identified as male (47%); 2,964 (52%) as female; and 52 (&lt; 1%) did not identify as either male or female.</p>
<sec><title>Preliminary Study of the ATOMS</title>
<p>We performed a preliminary study to examine corrected item-total score correlations and explore underlying factors of the initial instrument (14-item). The corrected item-total score correlations were all positive and statistically significant with the exception of one item that read: &#x201C;A patient is healed when the underlying pathological processes are corrected or controlled&#x201D;, for which the item-total score correlation was negative and negligible (r=-0.10), with a non-substantial factor loading. We deleted this item; thus, the final ATOMS contained 13 items used for further statistical analyses (see Appendix A).</p>
</sec><sec><title>Item-Total Score Correlations</title>
<p>The corrected item-total score correlations of the final 13-item ATOMS instrument (calculated based on the correlation between each item score and total score, excluding the corresponding item from the total score) were statistically significant and moderately high, ranging from a low of 0.29 (p&lt; 0.01) for this item: &#x201C;Therapeutic touch has been discredited as a healing modality&#x201D; (a reverse-scored item) to a high of 0.61, p&lt;0.01) for this item: &#x201C;Osteopathic manipulative therapy is a valuable method for resolving a wide variety of musculoskeletal problems&#x201D;. The median correlation was 0.49 (<xref ref-type="table" rid="t1">Table 1</xref>).</p>
			
</sec>
	
<sec><title>Effect Sizes of Item Discrimination Indices</title>
<p>The effect sizes of item discrimination indices were calculated by subtracting the item mean score for the top 33% ATOMS scorers from the mean score of the same item obtained by the bottom 33% ATOMS scorers, divided by the pooled standard deviation of the corresponding item (<xref ref-type="table" rid="t1">Table 1</xref>). These effect sizes were analogous to Cohen&#x2019;s d statistics.<xref ref-type="bibr" rid="r32"><sup>32</sup></xref> All of the effect sizes were substantially large (&gt; 1.01).</p>
</sec><sec><title>Exploratory Factor Analysis</title>
<p>We examined the underlying construct of the 13-item ATOMS by conducting exploratory factor analysis, using principal components with oblique (promax) rotation to allow correlations among the factors (<xref ref-type="table" rid="t1">Table 1</xref>). Three factors emerged, each with an eigenvalue greater than 1 (Kaiser Criterion). The eigenvalues before rotation were 4.41, 1.59, and 1.04, and accounted for 34%, 12%, and 8% of the total variance, respectively. The scree test showed that the plot of eigenvalues leveled off after the third extracted factor, supporting the retention of the three factors. The Kaiser-Meyer-Olkin measure of sampling adequacy (MSA) showed an overall index of 0.88, indicating that data were adequate for factor analysis. Bartlett&#x2019;s test for sphericity indicated that the intercorrelation matrix was factorable (&#x3C7;<sup>2</sup><sub>(42)=</sub>463.82, p&lt;0.0001).</p>
<p>The first factor was entitled &#x201C;Perspectives on Osteopathic Medicine&#x201D; (rotated factor loadings &#x2265; 0.42 in its five items). A typical item representing this factor is: &#x201C;A strong relationship between patient and physician is an extremely valuable therapeutic intervention that leads to improved outcomes.&#x201D; The second factor, &#x201C;Osteopathic Diagnosis and Treatment&#x201D;, included five items with factor loadings &#x2265; 0.46. A typical item representing this factor is: &#x201C;Touch and tactile approaches may not serve a significant purpose in patient care&#x201D; (a reverse-scored item). The third factor, &#x201C;Holistic-Integrative Care&#x201D;, included three items with factor loadings &#x2265; 0.54. A typical item representing this factor is: &#x201C;The osteopathic philosophy of holistic care greatly influenced my decision to attend an osteopathic school.&#x201D; The Cronbach&#x2019;s coefficient alphas for the three extracted factors were 0.77, 0.71, and 0.73, respectively.</p>
</sec><sec><title>Descriptive Statistics</title>
<p>The obtained mean and standard deviation of ATOMS scores were 73.9 and 9.5, respectively; the possible and actual score ranges were 13-91 and 29-91, respectively.</p>
</sec><sec><title>Criterion-Related Validity</title>
<p>We examined bivariate Pearson correlations between scores on the ATOMS and those of other personal quality measures used in the study (<xref ref-type="table" rid="t2">Table 2</xref>). All obtained correlations were statistically significant, ranging from highs of 0.60 (p&lt;0.01) for interprofessional collaboration, and 0.58 (p&lt;0.01) for clinical empathy, to a low of 0.17 (p&lt; 0.01) for emotional empathy. Correlation between scores of the ATOMS and burnout measure was statistically significant and negative (r= -0.29, p&lt; 0.01).</p>
<p>We performed multiple regression analysis to examine the unique contribution of each of the personal quality measures in predicting scores on the ATOMS. <xref ref-type="table" rid="t2">Table 2</xref> shows standardized regression coefficients (&#x3B2;), unstandardized regression coefficients, standard errors, t-values, and statistical significance for the unique contributions of the regressors in predicting ATOMS scores.</p>
<p>Measures of interprofessional collaboration (&#x3B2;=0.33), and clinical empathy (&#x3B2;=0.30) provided the most unique and positive contributions to predicting ATOMS scores in the multivariate model, and orientation toward lifelong learning (&#x3B2;=0.13) and emotional empathy (&#x3B2;=0.08) provided the least. The burnout measure showed a statistically significant negative contribution. The adjusted multiple correlation was R=0.68, meaning that 46% (R<sup>2</sup>=0.68<sup>2</sup>=46%) of the variation in the ATOMS scores could be accounted for by the five regressors (<xref ref-type="table" rid="t2">Table 2</xref>).</p>
<p>In the additional analysis, we found a significant inverse association between clinical (cognitive) empathy and burnout (r=-0.21, p &lt;0.01), whereas the correlation between emotional empathy and burnout was positive (r=0.14, p&lt;0.01). This pattern of finding was expected as described in the discussion of findings.</p>
				
</sec>
				
<sec><title>Validity Evidence by the Method of Contrasted Groups</title>
<p>Significant differences have been found on scores on the JSE and gender (in favor of women),<xref ref-type="bibr" rid="r12"><sup>12</sup></xref><sup>,</sup><xref ref-type="bibr" rid="r31"><sup>31</sup></xref> and on ethnicity (in favor of African-American and Latinx vs Asian-American and White medical students),<xref ref-type="bibr" rid="r31"><sup>31</sup></xref> &#xA0;&#xA0;academic background (in favor</p>


<table-wrap id="t1" position="float"><label>Table 1</label><caption><title>Rotated Factor Loadings(a), Corrected Item-Total Score Correlations(b), and Effect Sizes of Item Discrimination Indices(c) for the Attitudes Toward Osteopathic Medicine Scale (ATOMS) in a National Sample of First Year Matriculants of 33 U.S. Colleges of Osteopathic Medicine</title></caption>
<table width="100%">
<thead><tr style="border-top: 1pt solid; border-bottom: 1pt solid;">
<th align="left" style="border-top: 1pt solid; border-bottom: 1pt solid; width: 49%;">Item</th>
<th align="left" style="border-top: 1pt solid; border-bottom: 1pt solid; width: 9%;">Factor1</th>
<th align="left" style="border-top: 1pt solid; border-bottom: 1pt solid; width: 9%;">Factor2</th>
<th align="left" style="border-top: 1pt solid; border-bottom: 1pt solid; width: 9%;">Factor3</th>
<th align="left" style="border-top: 1pt solid; border-bottom: 1pt solid; width: 9%;">
Corrected item-total score
correlation
</th>
<th align="left" style="border-top: 1pt solid; border-bottom: 1pt solid; width: 13%;">
Item
discrimination
index effect size
</th>
</tr></thead>
<tbody>
<tr>
<td align="left" style="width: 49%;">Physicians who strive to understand themselves provide better care than those who do not. (10)</td>
<td align="left" style="width: 9%;">0.75</td>
<td align="left" style="width: 9%;">0.00</td>
<td align="left" style="width: 9%;">-0.02</td>
<td align="left" style="width: 9%;">0.51</td>
<td align="left" style="width: 13%;">1.40</td>
</tr>
<tr>
<td align="left" style="width: 49%;">Physicians who model a balanced lifestyle (i.e., Attending to their own health, social, family and spiritual needs, as well as interests beyond medicine) generate improved patient satisfaction. (4)</td>
<td align="left" style="width: 9%;">0.68</td>
<td align="left" style="width: 9%;">-0.02</td>
<td align="left" style="width: 9%;">0.04</td>
<td align="left" style="width: 9%;">0.49</td>
<td align="left" style="width: 13%;">1.25</td>
</tr>
<tr>
<td align="left" style="width: 49%;">A strong relationship between patient and physician is an extremely valuable therapeutic intervention that leads to improved outcomes. (6)</td>
<td align="left" style="width: 9%;">0.65</td>
<td align="left" style="width: 9%;">0.08</td>
<td align="left" style="width: 9%;">0.02</td>
<td align="left" style="width: 9%;">0.54</td>
<td align="left" style="width: 13%;">1.44</td>
</tr>
<tr>
<td align="left" style="width: 49%;">Psychosocial factors are as important as biomedical factor in health and illness. (11)</td>
<td align="left" style="width: 9%;">0.54</td>
<td align="left" style="width: 9%;">0.09</td>
<td align="left" style="width: 9%;">0.04</td>
<td align="left" style="width: 9%;">0.47</td>
<td align="left" style="width: 13%;">1.25</td>
</tr>
<tr>
<td align="left" style="width: 49%;">Instilling hope in patients is a physician&#x2019;s duty. (7)</td>
<td align="left" style="width: 9%;">0.42</td>
<td align="left" style="width: 9%;">-0.11</td>
<td align="left" style="width: 9%;">0.13</td>
<td align="left" style="width: 9%;">0.31</td>
<td align="left" style="width: 13%;">1.02</td>
</tr>
<tr>
<td align="left" style="width: 49%;">Medical problems need specific medical and surgical interventions, thus, holistic approaches to medical problems cannot be as beneficial as targeted biomedical treatment. (12)</td>
<td align="left" style="width: 9%;">0.05</td>
<td align="left" style="width: 9%;">0.67</td>
<td align="left" style="width: 9%;">-0.05</td>
<td align="left" style="width: 9%;">0.48</td>
<td align="left" style="width: 13%;">1.56</td>
</tr>
<tr>
<td align="left" style="width: 49%;">Touch and tactile approaches may not serve a significant purpose in patient care. (13)</td>
<td align="left" style="width: 9%;">0.08</td>
<td align="left" style="width: 9%;">0.62</td>
<td align="left" style="width: 9%;">0.03</td>
<td align="left" style="width: 9%;">0.54</td>
<td align="left" style="width: 13%;">1.55</td>
</tr>
<tr>
<td align="left" style="width: 49%;">Osteopathic Manipulation often makes patients &#x201C;feel&#x201D; better temporarily but does not lead to objective improvement in long-term outcomes for patients. (5)</td>
<td align="left" style="width: 9%;">-0.12</td>
<td align="left" style="width: 9%;">0.52</td>
<td align="left" style="width: 9%;">0.32</td>
<td align="left" style="width: 9%;">0.54</td>
<td align="left" style="width: 13%;">1.67</td>
</tr>
<tr>
<td align="left" style="width: 49%;">Information about the relative effectiveness of treatments that is obtained by research methods other than randomized controlled trials has little value to physicians. (9)</td>
<td align="left" style="width: 9%;">-0.02</td>
<td align="left" style="width: 9%;">0.48</td>
<td align="left" style="width: 9%;">-0.03</td>
<td align="left" style="width: 9%;">0.32</td>
<td align="left" style="width: 13%;">1.15</td>
</tr>
<tr>
<td align="left" style="width: 49%;">Therapeutic touch has been completely discredited as a healing modality. (3)</td>
<td align="left" style="width: 9%;">-0.01</td>
<td align="left" style="width: 9%;">0.46</td>
<td align="left" style="width: 9%;">-0.05</td>
<td align="left" style="width: 9%;">0.29</td>
<td align="left" style="width: 13%;">1.09</td>
</tr>
<tr>
<td align="left" style="width: 49%;">Osteopathic manipulative therapy is a valuable method for resolving a wide variety of musculoskeletal problems (beyond back pain). (8)</td>
<td align="left" style="width: 9%;">0.07</td>
<td align="left" style="width: 9%;">0.06</td>
<td align="left" style="width: 9%;">0.71</td>
<td align="left" style="width: 9%;">0.61</td>
<td align="left" style="width: 13%;">1.72</td>
</tr>
<tr>
<td align="left" style="width: 49%;">The osteopathic philosophy of holistic care greatly influenced my decision to attend an osteopathic school. (1)</td>
<td align="left" style="width: 9%;">0.05</td>
<td align="left" style="width: 9%;">0.00</td>
<td align="left" style="width: 9%;">0.66</td>
<td align="left" style="width: 9%;">0.51</td>
<td align="left" style="width: 13%;">1.42</td>
</tr>
<tr>
<td align="left" style="width: 49%;">Patients whose physicians are knowledgeable of multiple medical systems and complementary and alternative practices, in addition to conventional medicine, do better than those whose physicians are only familiar with conventional medicine. (2)</td>
<td align="left" style="width: 9%;">0.18</td>
<td align="left" style="width: 9%;">-0.06</td>
<td align="left" style="width: 9%;">0.54</td>
<td align="left" style="width: 9%;">0.49</td>
<td align="left" style="width: 13%;">1.45</td>
</tr>
<tr style="border-bottom: 1pt solid;">
<td align="left" style="border-bottom: 1pt solid; width: 49%;">Eigenvalue</td>
<td align="left" style="border-bottom: 1pt solid; width: 9%;">4.41</td>
<td align="left" style="border-bottom: 1pt solid; width: 9%;">1.59</td>
<td align="left" style="border-bottom: 1pt solid; width: 9%;">1.04</td>
<td align="left" style="border-bottom: 1pt solid; width: 9%;">&#xA0;</td>
<td align="left" style="border-bottom: 1pt solid; width: 13%;">&#xA0;</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
	
<p><sup>(a) </sup>Based on the content of items with high factor loadings, Factor 1: was entitled &#x201C;Perspectives on Osteopathic Medicine&#x201D;, Factor 2: &#x201C;Osteopathic Diagnosis and Treatment&#x201D;, and Factor 3: &#x201C;Holistic-Integrative Care&#x201D;.&#xA0;&#xA0; Items are sorted by descending order of factor loadings within each factor. Number in parentheses refer to the appearance of the items in the ATOMS.</p>
<p><sup>(b) </sup>Correlations between scores on each item and the ATOMS total score by excluding the corresponding item from the total score, all were statistically significant (p&lt; 0.01).</p>
<p><sup>(c) </sup>Effect size estimate (Cohen&#x2019;s d statistic) of the discrimination index was calculated by subtracting the item mean score of the ATOMS high scorers (top 33%) from the item mean score of the ATOMS low scorers (bottom 33%), divided by the pooled standard deviation of the corresponding item.</p>
	
</table-wrap-foot></table-wrap>
		
<p>of those with undergraduate college majors (in favor of those with college majors in social and behavioral sciences, and arts and humanities)<xref ref-type="bibr" rid="r31"><sup>31</sup></xref> and career interest (in favor of medical students who planned to pursue &#x201C;People-Oriented&#x201D; specialties such as general internal medicine, family medicine, pediatrics, and psychiatry versus others interested in &#x201C;Technology/Procedure-Oriented&#x201D; specialties such as pathology, anesthesiology, radiology, and surgery.<xref ref-type="bibr" rid="r12"><sup>12</sup></xref><sup>,</sup><xref ref-type="bibr" rid="r31"><sup>31</sup></xref> Because of significant and relatively large correlations we observed in this study between the ATOMS and JSE scores, we expected to similarly find significant differences on scores of the ATOMS by gender (in favor of women), ethnicity (in favor of African-American and Latinx), academic background (in favor of those with college majors in social and behavioral sciences, arts and humanities), and career interest (in favor of those planning to pursue &#x201C;People-Oriented&#x201D; specialties). Using analysis of variance, we examined group differences on the ATOMS scores by gender, race/ethnicity, academic background, and career interest to find out if group differences were in the expected direction. Means, standard deviations, and summary results of statistical analyses are reported in <xref ref-type="table" rid="t3">Table 3</xref>.</p>
	
</sec><sec><title>Gender Difference</title>
<p>The ATOMS mean score for men was 71.5 (SD=10.0), and for women was 76.1 (SD=8.3). Gender difference in favor of women was statistically significant (F<sub>(</sub><sub>1,5615)</sub>=362.31, p&lt; 0.0001). The difference was also practically important, as indicated by the effect size of 0.51.</p>
				
<table-wrap id="t2" position="float"><label>Table 2</label><caption><title>Summary Results of Multiple Regression Analysis(a) in a National Sample of First Year Matriculants of 33 U.S. Colleges of Osteopathic Medicine
</title></caption>
<table width="100%">
<thead><tr style="border-top: 1pt solid; border-bottom: 1pt solid;">
<th align="left" style="border-top: 1pt solid; border-bottom: 1pt solid; width: 11%;">Regressors</th>
<th align="left" style="border-top: 1pt solid; border-bottom: 1pt solid; width: 14%;">Bivariate correlation<sup>(b)</sup>
</th>
<th align="left" style="border-top: 1pt solid; border-bottom: 1pt solid; width: 22%;">
Standardized
regression coefficient (&#x3B2;)<sup>(c)</sup>
</th>
<th align="left" style="border-top: 1pt solid; border-bottom: 1pt solid; width: 20%;">Unstandardized regression coefficient<sup>(d)</sup>
</th>
<th align="left" style="border-top: 1pt solid; border-bottom: 1pt solid; width: 13%;">Standard error</th>
<th align="left" style="border-top: 1pt solid; border-bottom: 1pt solid; width: 17%;">t-value</th>
</tr></thead>
<tbody>
<tr>
<td align="left" style="width: 11%;">JSE</td>
<td align="left" style="width: 14%;">0.58<sup>**</sup>
</td>
<td align="left" style="width: 22%;">0.30</td>
<td align="left" style="width: 20%;">0.25</td>
<td align="left" style="width: 13%;">0.01</td>
<td align="left" style="width: 17%;">23.00<sup>**</sup>
</td>
</tr>
<tr>
<td align="left" style="width: 11%;">IRI</td>
<td align="left" style="width: 14%;">0.17<sup>**</sup>
</td>
<td align="left" style="width: 22%;">0.08</td>
<td align="left" style="width: 20%;">0.13</td>
<td align="left" style="width: 13%;">0.02</td>
<td align="left" style="width: 17%;">7.50<sup>**</sup>
</td>
</tr>
<tr>
<td align="left" style="width: 11%;">JeffSATIC
</td>
<td align="left" style="width: 14%;">0.60<sup>**</sup>
</td>
<td align="left" style="width: 22%;">0.33</td>
<td align="left" style="width: 20%;">0.25</td>
<td align="left" style="width: 13%;">0.01</td>
<td align="left" style="width: 17%;">25.08<sup>**</sup>
</td>
</tr>
<tr>
<td align="left" style="width: 11%;">JSPLL
</td>
<td align="left" style="width: 14%;">0.36<sup>**</sup>
</td>
<td align="left" style="width: 22%;">0.13</td>
<td align="left" style="width: 20%;">0.22</td>
<td align="left" style="width: 13%;">0.02</td>
<td align="left" style="width: 17%;">11.73<sup>**</sup>
</td>
</tr>
<tr>
<td align="left" style="width: 11%;">BM
</td>
<td align="left" style="width: 14%;">-0.29<sup>**</sup>
</td>
<td align="left" style="width: 22%;">-0.12</td>
<td align="left" style="width: 20%;">-1.27</td>
<td align="left" style="width: 13%;">0.11</td>
<td align="left" style="width: 17%;">-11.57<sup>**</sup>
</td>
</tr>
<tr style="border-bottom: 1pt solid;">
<td align="left" style="border-bottom: 1pt solid; width: 11%;">Intercept</td>
<td align="left" style="border-bottom: 1pt solid; width: 14%;">-</td>
<td align="left" style="border-bottom: 1pt solid; width: 22%;">0</td>
<td align="left" style="border-bottom: 1pt solid; width: 20%;">3.62</td>
<td align="left" style="border-bottom: 1pt solid; width: 13%;">1.33</td>
<td align="left" style="border-bottom: 1pt solid; width: 17%;">2.73<sup>*</sup>
</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
	
<p><sup>**</sup>p&lt;0.0001, <sup>*</sup>p&lt;0.05, adjusted multiple R = 0.68, p&lt;0.0001</p>
<p><sup>(a) </sup>Scores on the Attitudes Toward Osteopathic Medicine Scale (ATOMS) as the dependent variable, and personality measures as regressors.</p>
<p><sup>(b)</sup> Bivariate correlation between the ATOMS scores and other personality measures shown in the table.</p>
<p><sup>(c)</sup>Standardized regression coefficients (&#x3B2;) are calculated from score distributions converted to a standard distribution for all regressors with a mean of zero and standard deviation of 1 for comparability purposes.</p>
<p><sup>(d)</sup>Unstandardized regression coefficients are calculated from raw score distributions.</p>
<p>Abbreviations: JSE: Jefferson Scale of Empathy; IRI: Interpersonal Reactivity Index; JeffSATIC:&#xA0; Jefferson Scale of Attitudes Toward Interprofessional Collaboration; JSPLL: Jefferson Scale of Physician Lifelong Learning; BM: Shirom-Melamed Burnout Measure.</p>
	
</table-wrap-foot></table-wrap>
		

</sec><sec><title>Race/Ethnicity Differences</title>
<p>The highest mean score on the ATOMS was obtained by Black/African American students (M=77.27, SD=9.2), and the lowest by Asian students (M=72.88, SD=9.5). The mean scores of the White and Hispanic/Latinx/Spanish origin groups were in between the other two groups. The differences in favor of the African/American group versus Asian, White, and Hispanic/Latinx/Spanish origin groups were statistically significant (F<sub>(</sub><sub>3,5099)</sub>=15.80, p&lt;.0001). Also, Hispanic/Latinx/Spanish origin groups obtained mean scores that were significantly higher than those obtained by White and Asian groups. The race/ethnic differences were practically important (effect size between the highest and lowest scoring groups=0.47).</p>
</sec><sec><title>Academic Background</title>
<p>Respondents were asked to report their undergraduate major by choosing from a list of 56 undergraduate majors (sorted alphabetically). For statistical analysis, we grouped the undergraduate majors into the following four broad categories: &#x201C;Biological Sciences,&#x201D; &#x201C;Chemical/Physical Sciences,&#x201D; &#x201C;Social/Behavioral Sciences,&#x201D; and &#x201C;Arts and Humanities.&#x201D; We compared respondents with different undergraduate majors on ATOMS scores.</p>
<p>The majority reported their undergraduate degree in &#x201C;Biological Sciences&#x201D; (n=2,833), followed by those who majored in &#x201C;Chemical/Physical Sciences (n=755), &#x201C;Social/Behavioral Sciences&#x201D; (n=264), and &#x201C;Arts and Humanities&#x201D; (n=91). The lowest ATOMS mean score was obtained for those who majored in &#x201C;Chemical/Physical Sciences&#x201D; (M=71.8, SD=9.7), which was significantly lower than the scores in the other three academic background groups (F<sub>(</sub><sub>3,3939)</sub>=13.04, p&lt; .0001).</p>
</sec><sec><title>Career Interest</title>
<p>Respondents were asked to choose the specialty they planned to pursue after graduation from medical school from a list of 33 specialties, most frequently pursued by graduates of colleges of osteopathic medicine. Based on other studies with allopathic<xref ref-type="bibr" rid="r33"><sup>33</sup></xref> and osteopathic medical students,<xref ref-type="bibr" rid="r31"><sup>31</sup></xref> we divided the specialties into three broad categories: &#x201C;People-Oriented&#x201D; (e.g., family medicine, internal medicine, obstetrics and gynecology, and pediatrics); &#x201C;Technology-/Procedure-Oriented&#x201D; (e.g., anesthesiology, dermatology, ophthalmology, orthopedic surgery, radiology, and surgery); and &#x201C;Other&#x201D; (including specialties chosen by fewer than 20 matriculants).</p>
<p>Summary results of statistical analyses are reported in <xref ref-type="table" rid="t3">Table 3</xref>. The highest ATOMS mean score was obtained by those planning to pursue &#x201C;People-Oriented&#x201D; specialties (M=75,17, SD=9.0), and the lowest by those planning to pursue &#x201C;Technology-/Procedure-Oriented&#x201D; specialties (M=72.55, SD=9.9) (F<sub>(</sub><sub>2,5110)</sub>=40.21, p&lt;0.0001).</p>
</sec>
	
<sec><title>National norms</title>
<p>Using a national sample in this study provided a unique opportunity to develop national norms for the ATOMS scores that will enable medical colleges to determine the percentile rank of any new matriculant to osteopathic medical schools. Because of the gender difference in ATOMS scores observed in this study, we calculated percentile ranks for men and women separately (<xref ref-type="table" rid="t4">Table 4</xref>). For example, if the ATOMS score of a male matriculant is 80, first find the score interval that includes a score of 80 (79-80 score interval in <xref ref-type="table" rid="t4">Table 4</xref>), then find the corresponding national percentile rank displayed in the row for that score interval in the table. The corresponding national percentile rank in the table for a male matriculant with an ATOMS score of 80 is 78%, meaning that a score of 80 places a male matriculant in the 78th percentile rank of all first-year male matriculants. However, a female matriculant with an ATOMS score of 80 would be at the 61st percentile rank. If the gender is unknown, then the percentile rank on the norm table for men and women combined can be used to estimate.</p>
		
	  
<table-wrap id="t3" position="float"><label>Table 3</label><caption><title>Comparisons of Scores of the Attitudes Toward Osteopathic Medicine Scale (ATOMS) by Gender, Race/Ethnicity, Academic Background and Career Interest in a National Sample of First Year Matriculants of 33 U.S. Colleges of Osteopathic Medicine
</title></caption>
<table width="100%">
<thead><tr style="border-top: 1pt solid; border-bottom: 1pt solid;">
<th colspan="2" align="left" style="border-top: 1pt solid; border-bottom: 1pt solid; width: 29%;">Variable</th>
<th align="left" style="border-top: 1pt solid; border-bottom: 1pt solid; width: 10%;">N</th>
<th align="left" style="border-top: 1pt solid; border-bottom: 1pt solid; width: 12%;">M</th>
<th align="left" style="border-top: 1pt solid; border-bottom: 1pt solid; width: 11%;">SD</th>
<th align="left" style="border-top: 1pt solid; border-bottom: 1pt solid; width: 22%;">F-ratio</th>
<th align="left" style="border-top: 1pt solid; border-bottom: 1pt solid; width: 13%;">p</th>
</tr></thead>
<tbody>
<tr><td colspan="7" align="left" style="width: 100%;">Gender<sup>(a)</sup>
</td></tr>
<tr>
<td align="left" style="width: 3%;">&#xA0;</td>
<td align="left" style="width: 25%;">Men</td>
<td align="left" style="width: 10%;">2653</td>
<td align="left" style="width: 12%;">71.5</td>
<td align="left" style="width: 11%;">10</td>
<td rowspan="2" align="left" style="width: 22%;">F<sub>(</sub><sub>1,5615)</sub> = 362.31</td>
<td rowspan="2" align="left" style="width: 13%;">p&lt;.0001</td>
</tr>
<tr>
<td align="left" style="width: 3%;">&#xA0;</td>
<td align="left" style="width: 25%;">Women</td>
<td align="left" style="width: 10%;">2964</td>
<td align="left" style="width: 12%;">76.1</td>
<td align="left" style="width: 11%;">8.3</td>
</tr>
<tr><td colspan="7" align="left" style="width: 100%;">Race/Ethnicity<sup>(b)</sup>
</td></tr>
<tr>
<td align="left" style="width: 3%;">&#xA0;</td>
<td align="left" style="width: 25%;">White/Caucasian</td>
<td align="left" style="width: 10%;">3386</td>
<td align="left" style="width: 12%;">73.94</td>
<td align="left" style="width: 11%;">9.4</td>
<td rowspan="4" align="left" style="width: 22%;">F<sub>(</sub><sub>3,5099)</sub> = 15.80</td>
<td rowspan="4" align="left" style="width: 13%;">p&lt;.0001</td>
</tr>
<tr>
<td align="left" style="width: 3%;">&#xA0;</td>
<td align="left" style="width: 25%;">Asian</td>
<td align="left" style="width: 10%;">1315</td>
<td align="left" style="width: 12%;">72.88</td>
<td align="left" style="width: 11%;">9.5</td>
</tr>
<tr>
<td align="left" style="width: 3%;">&#xA0;</td>
<td align="left" style="width: 25%;">Hispanic/Latinx/ Spanish origin</td>
<td align="left" style="width: 10%;">235</td>
<td align="left" style="width: 12%;">75.85</td>
<td align="left" style="width: 11%;">8.4</td>
</tr>
<tr>
<td align="left" style="width: 3%;">&#xA0;</td>
<td align="left" style="width: 25%;">Black/African American</td>
<td align="left" style="width: 10%;">167</td>
<td align="left" style="width: 12%;">77.27</td>
<td align="left" style="width: 11%;">9.2</td>
</tr>
<tr><td colspan="7" align="left" style="width: 100%;">Academic Background <sup>(c)</sup>
</td></tr>
<tr>
<td align="left" style="width: 3%;">&#xA0;</td>
<td align="left" style="width: 25%;">Biological Sciences</td>
<td align="left" style="width: 10%;">2833</td>
<td align="left" style="width: 12%;">74.12</td>
<td align="left" style="width: 11%;">9.3</td>
<td rowspan="4" align="left" style="width: 22%;">F<sub>(</sub><sub>3,3939)</sub> = 13.04</td>
<td rowspan="4" align="left" style="width: 13%;">p&lt;.0001</td>
</tr>
<tr>
<td align="left" style="width: 3%;">&#xA0;</td>
<td align="left" style="width: 25%;">Chemical/Physical Sciences</td>
<td align="left" style="width: 10%;">755</td>
<td align="left" style="width: 12%;">71.8</td>
<td align="left" style="width: 11%;">9.7</td>
</tr>
<tr>
<td align="left" style="width: 3%;">&#xA0;</td>
<td align="left" style="width: 25%;">Social/Behavioral Sciences</td>
<td align="left" style="width: 10%;">264</td>
<td align="left" style="width: 12%;">74.52</td>
<td align="left" style="width: 11%;">9.7</td>
</tr>
<tr>
<td align="left" style="width: 3%;">&#xA0;</td>
<td align="left" style="width: 25%;">Arts and Humanities</td>
<td align="left" style="width: 10%;">91</td>
<td align="left" style="width: 12%;">74.35</td>
<td align="left" style="width: 11%;">9.9</td>
</tr>
<tr><td colspan="7" align="left" style="width: 100%;">Career Interest<sup>(d)</sup>
</td></tr>
<tr style="border-bottom: 1pt solid;">
<td align="left" style="border-bottom: 1pt solid; width: 3%;">&#xA0;</td>
<td align="left" style="border-bottom: 1pt solid; width: 25%;">People-oriented</td>
<td align="left" style="border-bottom: 1pt solid; width: 10%;">2347</td>
<td align="left" style="border-bottom: 1pt solid; width: 12%;">75.17</td>
<td align="left" style="border-bottom: 1pt solid; width: 11%;">9</td>
<td rowspan="3" align="left" style="border-bottom: 1pt solid; width: 22%;">F<sub>(</sub><sub>2,5110)</sub> = 40.21</td>
<td rowspan="3" align="left" style="border-bottom: 1pt solid; width: 13%;">p&lt;.0001</td>
</tr>
<tr>
<td align="left" style="width: 3%;">&#xA0;</td>
<td align="left" style="width: 25%;">Technology- oriented</td>
<td align="left" style="width: 10%;">1542</td>
<td align="left" style="width: 12%;">72.55</td>
<td align="left" style="width: 11%;">9.9</td>
</tr>
<tr style="border-bottom: 1pt solid;">
<td align="left" style="border-bottom: 1pt solid; width: 3%;">&#xA0;</td>
<td align="left" style="border-bottom: 1pt solid; width: 25%;">Other</td>
<td align="left" style="border-bottom: 1pt solid; width: 10%;">1224</td>
<td align="left" style="border-bottom: 1pt solid; width: 12%;">73.25</td>
<td align="left" style="border-bottom: 1pt solid; width: 11%;">9.6</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
	
<p><sup>(a)</sup>Women &gt; Men, effect size= 0.51.</p>
<p><sup>(b)</sup> Black/African American &gt; Hispanic/Latinx/Spanish origin &gt; White/Caucasian and Asian, effect size = 0.47</p>
<p><sup>(c)</sup>Chemical/Physical Sciences &lt; all others, effect size = 0.28</p>
<p><sup>(d)</sup>People-oriented &gt; Other &gt; Technology-oriented, effect size = 0.28</p>
</table-wrap-foot></table-wrap>
</sec></sec>
	    
<sec sec-type="discussion"><title>Discussion</title>
<p>Using a nationwide sample, we developed and validated an instrument to measure students&#x2019; orientations toward osteopathic medicine. Moreover, the study allowed us to prepare national norms that will enable medical colleges to determine the percentile rank of first-year matriculants in U.S. osteopathic medical colleges. More importantly, in all statistical analyses, we controlled for the effect of social desirability bias by excluding those who attempted to give a &#x201C;good impression&#x201D; response and scored above the cutoff of the Infrequency scale of the Zuckerman-Kuhlman Personality Questionnaire.<xref ref-type="bibr" rid="r27"><sup>27</sup></xref></p>
<p>This study is unique, because to our knowledge, with the exception of studies in which we retrieved data from the Project in Osteopathic Medical Education and Empathy (POMEE), no other published study in medical education has been undertaken in which a large nationwide sample of medical students participated, and in which the social desirability response bias, which is a shortcoming of self-reported personality tests, was controlled.</p>
<p>Our findings on the magnitude and direction of item-total score correlations indicate that items of the ATOMS contribute significantly and positively to the total score. Cronbach&#x2019;s alpha coefficient of 0.83 for the ATOMS scores is in the acceptable range for psychological and educational tests. The large magnitude of effect sizes of item discrimination indices confirms the ability of ATOMS items to discriminate between students with the most favorable and the least favorable attitudes toward osteopathic medicine. The large magnitude of effect sizes indicate that the difference in mean item scores between high and low scorers in favor of high ATOMS scorers were not only statistically significant but also practically (clinically) important.<xref ref-type="bibr" rid="r32"><sup>32</sup></xref></p>
<p>The three underlying factors of the ATOMS that emerged from factor analysis not only corroborate the face and content validity of the instrument but also made it possible to recognize and quantify core components of orientation toward osteopathic medicine. The criterion-related validity of the ATOMS scores was supported by statistically significant and positive correlations with scores of conceptually relevant measures. In particular, higher correlations with scores from the orientation toward interprofessional collaboration and clinical empathy (conceptually more relevant to competencies of osteopathic medicine) support the &#x201C;convergent&#x201D; validity of ATOMS scores. Conversely, lower correlations with measures of attitudes toward lifelong learning and affective empathy (conceptually less relevant to core tenets of osteopathic medicine) support the &#x201C;discriminant&#x201D; validity of ATOMS scores.</p>
<p>Patterns of findings in the expected direction obtained by using the method of contrasted groups provided additional evidence in support of the validity of the ATOMS scores. Because of the significant correlation found between ATOMS and clinical empathy (JSE) scores, we expected to find group differences similar to those in our previous research on empathy. For example, the ATOMS mean score was significantly higher for women than for men, a pattern of difference observed for clinical empathy in allopathic<xref ref-type="bibr" rid="r33"><sup>33</sup></xref><sup>,</sup><xref ref-type="bibr" rid="r34"><sup>34</sup></xref>&#xA0; and osteopathic medical students.<xref ref-type="bibr" rid="r31"><sup>31</sup></xref> Also, group differences in ATOMS scores by race/ethnicity was consistent with previous findings regarding JSE scores in osteopathic medical students.<xref ref-type="bibr" rid="r31"><sup>31</sup></xref> Similarly, differences in ATOMS scores by academic background were consistent with previous findings regarding JSE scores among osteopathic medical students.<xref ref-type="bibr" rid="r31"><sup>31</sup></xref> Group differences in ATOMS scores by career interest were consistent with previous findings regarding JSE scores among allopathic<xref ref-type="bibr" rid="r33"><sup>33</sup></xref> and osteopathic medical students.<xref ref-type="bibr" rid="r31"><sup>31</sup></xref> &#xA0;</p>
<p>The inverse relationship between ATOMS scores and burnout scores also supports the validity of ATOMS scores, consistent with other studies.<xref ref-type="bibr" rid="r35"><sup>35</sup></xref> Additional research is needed to explain the difference in the direction of correlation between ATOMS scores and clinical empathy scores as opposed to emotional empathy scores. Perhaps the cognitive nature of clinical empathy (measured by the JSE) as opposed to affective nature of emotional empathy (measured by the subscales of the IRI) could explain their corresponding positive and negative correlations with the ATOMS scores.</p>
<p>A limitation of the findings is that national norms developed for new matriculants cannot be used for students in different years of medical school unless further empirical evidence verifies that ATOMS scores do not significantly change as students progress through medical school, which seems unlikely, based on previous findings.<xref ref-type="bibr" rid="r6"><sup>6</sup></xref><sup>,</sup><xref ref-type="bibr" rid="r30"><sup>30</sup></xref></p>
		
<table-wrap id="t4" position="float"><label>Table 4</label><caption><title>National Norm Table for the Attitudes Toward Osteopathic Medicine Scale (ATOMS) in a National Sample of First Year Matriculants from 33 U.S. Colleges of Osteopathic Medicine</title></caption>
<table width="100%">
<thead>
<tr style="border-top: 1pt solid; border-bottom: 1pt solid;">
<th align="left" style="border-top: 1pt solid; border-bottom: 1pt solid; width: 11%;">ATOM</th>
<th colspan="3" align="left" style="border-top: 1pt solid; border-bottom: 1pt solid; width: 29%;">Men (n=2653)</th>
<th colspan="3" align="left" style="border-top: 1pt solid; border-bottom: 1pt solid; width: 29%;">Women (n=2964)</th>
<th colspan="3" align="left" style="border-top: 1pt solid; border-bottom: 1pt solid; width: 29%;">Combined (n=5617)</th>
</tr>
<tr style="border-top: 1pt solid; border-bottom: 1pt solid;">
<th align="left" style="border-top: 1pt solid; border-bottom: 1pt solid; width: 11%;">Raw Scores</th>
<th align="left" style="border-top: 1pt solid; border-bottom: 1pt solid; width: 7%;">f</th>
<th align="left" style="border-top: 1pt solid; border-bottom: 1pt solid; width: 11%;">cf</th>
<th align="left" style="border-top: 1pt solid; border-bottom: 1pt solid; width: 10%;">%Tile Rank</th>
<th align="left" style="border-top: 1pt solid; border-bottom: 1pt solid; width: 11%;">f</th>
<th align="left" style="border-top: 1pt solid; border-bottom: 1pt solid; width: 7%;">cf</th>
<th align="left" style="border-top: 1pt solid; border-bottom: 1pt solid; width: 10%;">%Tile Rank</th>
<th align="left" style="border-top: 1pt solid; border-bottom: 1pt solid; width: 10%;">f</th>
<th align="left" style="border-top: 1pt solid; border-bottom: 1pt solid; width: 7%;">cf</th>
<th align="left" style="border-top: 1pt solid; border-bottom: 1pt solid; width: 11%;">%Tile Rank</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" style="width: 11%;">&#x2264; 46</td>
<td align="left" style="width: 7%;">17</td>
<td align="left" style="width: 11%;">17</td>
<td align="left" style="width: 10%;">&lt;1</td>
<td align="left" style="width: 11%;">1</td>
<td align="left" style="width: 7%;">1</td>
<td align="left" style="width: 10%;">&lt;1</td>
<td align="left" style="width: 10%;">18</td>
<td align="left" style="width: 7%;">18</td>
<td align="left" style="width: 11%;">&lt;1</td>
</tr>
<tr>
<td align="left" style="width: 11%;">47-48</td>
<td align="left" style="width: 7%;">14</td>
<td align="left" style="width: 11%;">31</td>
<td align="left" style="width: 10%;">1</td>
<td align="left" style="width: 11%;">1</td>
<td align="left" style="width: 7%;">2</td>
<td align="left" style="width: 10%;">&lt;1</td>
<td align="left" style="width: 10%;">15</td>
<td align="left" style="width: 7%;">33</td>
<td align="left" style="width: 11%;">&lt;1</td>
</tr>
<tr>
<td align="left" style="width: 11%;">53-54</td>
<td align="left" style="width: 7%;">46</td>
<td align="left" style="width: 11%;">154</td>
<td align="left" style="width: 10%;">5</td>
<td align="left" style="width: 11%;">10</td>
<td align="left" style="width: 7%;">42</td>
<td align="left" style="width: 10%;">1</td>
<td align="left" style="width: 10%;">56</td>
<td align="left" style="width: 7%;">196</td>
<td align="left" style="width: 11%;">3</td>
</tr>
<tr>
<td align="left" style="width: 11%;">55-56</td>
<td align="left" style="width: 7%;">65</td>
<td align="left" style="width: 11%;">219</td>
<td align="left" style="width: 10%;">7</td>
<td align="left" style="width: 11%;">18</td>
<td align="left" style="width: 7%;">60</td>
<td align="left" style="width: 10%;">2</td>
<td align="left" style="width: 10%;">83</td>
<td align="left" style="width: 7%;">279</td>
<td align="left" style="width: 11%;">4</td>
</tr>
<tr>
<td align="left" style="width: 11%;">57-58</td>
<td align="left" style="width: 7%;">75</td>
<td align="left" style="width: 11%;">294</td>
<td align="left" style="width: 10%;">10</td>
<td align="left" style="width: 11%;">25</td>
<td align="left" style="width: 7%;">85</td>
<td align="left" style="width: 10%;">2</td>
<td align="left" style="width: 10%;">100</td>
<td align="left" style="width: 7%;">379</td>
<td align="left" style="width: 11%;">6</td>
</tr>
<tr>
<td align="left" style="width: 11%;">59-60</td>
<td align="left" style="width: 7%;">99</td>
<td align="left" style="width: 11%;">393</td>
<td align="left" style="width: 10%;">13</td>
<td align="left" style="width: 11%;">42</td>
<td align="left" style="width: 7%;">127</td>
<td align="left" style="width: 10%;">4</td>
<td align="left" style="width: 10%;">141</td>
<td align="left" style="width: 7%;">520</td>
<td align="left" style="width: 11%;">8</td>
</tr>
<tr>
<td align="left" style="width: 11%;">61-62</td>
<td align="left" style="width: 7%;">109</td>
<td align="left" style="width: 11%;">502</td>
<td align="left" style="width: 10%;">17</td>
<td align="left" style="width: 11%;">74</td>
<td align="left" style="width: 7%;">201</td>
<td align="left" style="width: 10%;">6</td>
<td align="left" style="width: 10%;">183</td>
<td align="left" style="width: 7%;">703</td>
<td align="left" style="width: 11%;">11</td>
</tr>
<tr>
<td align="left" style="width: 11%;">63-64</td>
<td align="left" style="width: 7%;">119</td>
<td align="left" style="width: 11%;">621</td>
<td align="left" style="width: 10%;">21</td>
<td align="left" style="width: 11%;">84</td>
<td align="left" style="width: 7%;">285</td>
<td align="left" style="width: 10%;">8</td>
<td align="left" style="width: 10%;">203</td>
<td align="left" style="width: 7%;">906</td>
<td align="left" style="width: 11%;">14</td>
</tr>
<tr>
<td align="left" style="width: 11%;">65-66</td>
<td align="left" style="width: 7%;">157</td>
<td align="left" style="width: 11%;">778</td>
<td align="left" style="width: 10%;">26</td>
<td align="left" style="width: 11%;">97</td>
<td align="left" style="width: 7%;">382</td>
<td align="left" style="width: 10%;">11</td>
<td align="left" style="width: 10%;">254</td>
<td align="left" style="width: 7%;">1160</td>
<td align="left" style="width: 11%;">18</td>
</tr>
<tr>
<td align="left" style="width: 11%;">67-68</td>
<td align="left" style="width: 7%;">183</td>
<td align="left" style="width: 11%;">961</td>
<td align="left" style="width: 10%;">33</td>
<td align="left" style="width: 11%;">135</td>
<td align="left" style="width: 7%;">517</td>
<td align="left" style="width: 10%;">15</td>
<td align="left" style="width: 10%;">318</td>
<td align="left" style="width: 7%;">1478</td>
<td align="left" style="width: 11%;">23</td>
</tr>
<tr>
<td align="left" style="width: 11%;">69-70</td>
<td align="left" style="width: 7%;">186</td>
<td align="left" style="width: 11%;">1147</td>
<td align="left" style="width: 10%;">40</td>
<td align="left" style="width: 11%;">172</td>
<td align="left" style="width: 7%;">689</td>
<td align="left" style="width: 10%;">20</td>
<td align="left" style="width: 10%;">358</td>
<td align="left" style="width: 7%;">1836</td>
<td align="left" style="width: 11%;">29</td>
</tr>
<tr>
<td align="left" style="width: 11%;">71-72</td>
<td align="left" style="width: 7%;">230</td>
<td align="left" style="width: 11%;">1377</td>
<td align="left" style="width: 10%;">48</td>
<td align="left" style="width: 11%;">248</td>
<td align="left" style="width: 7%;">937</td>
<td align="left" style="width: 10%;">27</td>
<td align="left" style="width: 10%;">478</td>
<td align="left" style="width: 7%;">2314</td>
<td align="left" style="width: 11%;">37</td>
</tr>
<tr>
<td align="left" style="width: 11%;">73-74</td>
<td align="left" style="width: 7%;">220</td>
<td align="left" style="width: 11%;">1597</td>
<td align="left" style="width: 10%;">56</td>
<td align="left" style="width: 11%;">256</td>
<td align="left" style="width: 7%;">1193</td>
<td align="left" style="width: 10%;">36</td>
<td align="left" style="width: 10%;">476</td>
<td align="left" style="width: 7%;">2790</td>
<td align="left" style="width: 11%;">45</td>
</tr>
<tr>
<td align="left" style="width: 11%;">75-76</td>
<td align="left" style="width: 7%;">212</td>
<td align="left" style="width: 11%;">1809</td>
<td align="left" style="width: 10%;">64</td>
<td align="left" style="width: 11%;">259</td>
<td align="left" style="width: 7%;">1452</td>
<td align="left" style="width: 10%;">45</td>
<td align="left" style="width: 10%;">471</td>
<td align="left" style="width: 7%;">3261</td>
<td align="left" style="width: 11%;">54</td>
</tr>
<tr>
<td align="left" style="width: 11%;">77-78</td>
<td align="left" style="width: 7%;">181</td>
<td align="left" style="width: 11%;">1990</td>
<td align="left" style="width: 10%;">72</td>
<td align="left" style="width: 11%;">238</td>
<td align="left" style="width: 7%;">1690</td>
<td align="left" style="width: 10%;">53</td>
<td align="left" style="width: 10%;">419</td>
<td align="left" style="width: 7%;">3680</td>
<td align="left" style="width: 11%;">62</td>
</tr>
<tr>
<td align="left" style="width: 11%;">79-80</td>
<td align="left" style="width: 7%;">146</td>
<td align="left" style="width: 11%;">2136</td>
<td align="left" style="width: 10%;">78</td>
<td align="left" style="width: 11%;">249</td>
<td align="left" style="width: 7%;">1939</td>
<td align="left" style="width: 10%;">61</td>
<td align="left" style="width: 10%;">395</td>
<td align="left" style="width: 7%;">4075</td>
<td align="left" style="width: 11%;">69</td>
</tr>
<tr>
<td align="left" style="width: 11%;">81-82</td>
<td align="left" style="width: 7%;">148</td>
<td align="left" style="width: 11%;">2284</td>
<td align="left" style="width: 10%;">83</td>
<td align="left" style="width: 11%;">251</td>
<td align="left" style="width: 7%;">2190</td>
<td align="left" style="width: 10%;">70</td>
<td align="left" style="width: 10%;">399</td>
<td align="left" style="width: 7%;">4474</td>
<td align="left" style="width: 11%;">76</td>
</tr>
<tr>
<td align="left" style="width: 11%;">83-84</td>
<td align="left" style="width: 7%;">89</td>
<td align="left" style="width: 11%;">2373</td>
<td align="left" style="width: 10%;">88</td>
<td align="left" style="width: 11%;">279</td>
<td align="left" style="width: 7%;">2469</td>
<td align="left" style="width: 10%;">79</td>
<td align="left" style="width: 10%;">368</td>
<td align="left" style="width: 7%;">4842</td>
<td align="left" style="width: 11%;">83</td>
</tr>
<tr>
<td align="left" style="width: 11%;">85-86</td>
<td align="left" style="width: 7%;">111</td>
<td align="left" style="width: 11%;">2484</td>
<td align="left" style="width: 10%;">92</td>
<td align="left" style="width: 11%;">217</td>
<td align="left" style="width: 7%;">2686</td>
<td align="left" style="width: 10%;">87</td>
<td align="left" style="width: 10%;">328</td>
<td align="left" style="width: 7%;">5170</td>
<td align="left" style="width: 11%;">89</td>
</tr>
<tr>
<td align="left" style="width: 11%;">87-88</td>
<td align="left" style="width: 7%;">94</td>
<td align="left" style="width: 11%;">2578</td>
<td align="left" style="width: 10%;">95</td>
<td align="left" style="width: 11%;">151</td>
<td align="left" style="width: 7%;">2837</td>
<td align="left" style="width: 10%;">93</td>
<td align="left" style="width: 10%;">245</td>
<td align="left" style="width: 7%;">5415</td>
<td align="left" style="width: 11%;">94</td>
</tr>
<tr style="border-bottom: 1pt solid;">
<td align="left" style="border-bottom: 1pt solid; width: 11%;">&#x2265; 89</td>
<td align="left" style="border-bottom: 1pt solid; width: 7%;">75</td>
<td align="left" style="border-bottom: 1pt solid; width: 11%;">2653</td>
<td align="left" style="border-bottom: 1pt solid; width: 10%;">99</td>
<td align="left" style="border-bottom: 1pt solid; width: 11%;">127</td>
<td align="left" style="border-bottom: 1pt solid; width: 7%;">2964</td>
<td align="left" style="border-bottom: 1pt solid; width: 10%;">98</td>
<td align="left" style="border-bottom: 1pt solid; width: 10%;">202</td>
<td align="left" style="border-bottom: 1pt solid; width: 7%;">5617</td>
<td align="left" style="border-bottom: 1pt solid; width: 11%;">98</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p>f: Frequency, cf: Cumulative Frequency.</p>
<p>Respondents who did not specify their sex as &#x201C;male&#x201D; or &#x201C;female&#x201D; (&lt; 1%) were excluded in this table.</p>
</table-wrap-foot></table-wrap>

<p>The limitation regarding self-reported measures of personal attributes, influenced by social desirability response bias, could be mitigated by using the Infrequency Scale of the ZKPQ to control for &#x201C;good impression&#x201D; response bias.</p>
</sec>
    <sec sec-type="conclusions"><title>Conclusions</title>
<p>The ATOMS instrument, developed and validated in this study, benefits from strong psychometric support and brevity. It has important implications for assessing osteopathic educational outcomes (e.g., examining improvement in ATOMS scores as students progress through medical school, or exposed to a targeted educational program/workshop to enhance their understating of the philosophy and tenets of osteopathic medicine), and patient outcomes (e.g., associations between physicians&#x2019; ATOMS scores and positive patient or clinical outcomes). Furthermore, the national norms developed in this study have implications for admissions decisions (e.g., to recruit students who are more inclined to embrace the osteopathic philosophy, or simply to break the tie between applicants with similar academic credentials). Because of sound psychometric support (e.g., face, construct, criterion-related validity, and internal consistency reliability), brevity, unique advantage in using nationwide sample, and control for social desirability response bias, and because of visibility of POMEE in osteopathic medical education community, we anticipate broad use of the ATOMS in future osteopathic medical education research.</p>
		
<sec><title>Acknowledgements</title>
<p>We would like to acknowledge those who have contributed significantly to Phase II POMEE including the research coordinators who served as liaisons between their college and research teams at AACOM and Jefferson. They are: Michael Becker, DO, MS; Joseph Brewer, PhD, MD; Carla Case; Mark Clark, PhD; Karen Clayton, PhD; Robyn Dreibelbis, DO; Glenn Davis, MS; Kyle Henderson, PhD; Selma Holden, MD; Ana Maria Homs, PsyD, MBA; Justina Hyfantis, PhD; LeAnn Jons-Cox, DO; Schoen Kruse, PhD; Lisa Carroll, MD; Gretchen Lovett, PhD; Susan Mackintosh, DO, MPH; Patience Mason, MEd; Elizabeth McClain, PhD; Eric McLaughlin, MS; Terrence Miller, PhD; Luke Mortensen, PhD; Bruce Newton, PhD; Edward Magalhaes, PhD, LPC; Nagesh Rao, PhD; Lorree Ratto, PhD; Sean Reeder, DO; David Roos, EdD; Raquel Romanick, JD; Katherine Ruger, EdD; Vivian Stevens, PhD; Patricia Sexton, MS, DHEd; Vivian Stevens, PhD; Mary Ann Taylor, PhD; Clinton Whitson, MS; Rynn Ziller, EdD. Also, thanks to Aaron Douglas, PhD, and Bruce Newton, PhD, for their valuable comments; Shira Carroll, administrative assistant at Jefferson, for managing administrative aspects of the project in addition to editorial and stylistic modifications of the manuscript; and Pamela Walter for her editorial polishing help. We thank Dr. Craig D. Schneider for granting us permission to adapt and use 7 items from the Integrative Medicine Attitude Questionnaire, Dr. Mark Davis for granting us permission to use two scales of the IRI, and Dr. Samuel Melamed for his permission to use his burnout scale. We are also thankful to the deans of participating colleges of osteopathic medicine who notified and encouraged the study cohort in their schools to participate and continue their cooperation in the project, and finally we thank thousands of osteopathic medical students who participated in this study and completed the study survey.</p>
<sec><title>Funding support</title>
<p>This study was funded by the American Association of Colleges of Osteopathic Medicine (AACOM) and cosponsored by the American Osteopathic Association (AOA). The funding was terminated at the end of the 2019-2020 academic year, due to changes of leadership in the AOA and shift of research priority.</p>
</sec></sec></sec>
<sec><title>Conflict of Interest</title>
<p>The authors declare that they have no conflict of interest.</p>
</sec>
  </body>
  <back>
    <sec sec-type="supplementary-material"><title>Supplementary material</title>
<supplementary-material xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="S1.pdf" id="S1" mimetype="application/pdf"><label>Supplementary file 1</label><caption><p>Appendix A. Attitudes Toward Osteopathic Medicine Scale (ATOMS)</p></caption></supplementary-material></sec>
    <ref-list><title>References</title>
<ref id="r1"><label>1</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Carey</surname><given-names>TS</given-names></name><name><surname>Motyka</surname><given-names>TM</given-names></name><name><surname>Garrett</surname><given-names>JM</given-names></name><name><surname>Keller</surname><given-names>RB</given-names></name></person-group><article-title>Do osteopathic physicians differ in patient interaction from allopathic physicians? An empirically derived approach.</article-title><source>J Am Osteopath Assoc</source><year>2003</year><volume>103</volume><fpage>313</fpage><lpage>318</lpage><pub-id pub-id-type="pmid">12884943</pub-id></element-citation></ref><ref id="r2"><label>2</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Noll</surname><given-names>DR</given-names></name><name><surname>Ginsberg</surname><given-names>T</given-names></name><name><surname>Elahi</surname><given-names>A</given-names></name><name><surname>Cavalieri</surname><given-names>TA</given-names></name></person-group><article-title>Effective patient-physician communication based on osteopathic philosophy in caring for elderly patients.</article-title><source>J Am Osteopath Assoc</source><year>2016</year><volume>116</volume><fpage>42</fpage><lpage>47</lpage><pub-id pub-id-type="doi">10.7556/jaoa.2016.005</pub-id><pub-id pub-id-type="pmid">26745563</pub-id></element-citation></ref><ref id="r3"><label>3</label><mixed-citation publication-type="other">National Board of Osteopathic Medical Examiners (NBOME). Fundamental osteopathic medical competency domains. Chicago, IL: National Board of Osteopathic Medical Examiners. June 2011. [Cited 1 March 2021]; Available from: https://www.nbome.org/docs/NBOME%20Fundamental%20Osteopathic%20Medical%20Competencies.pdf. 
</mixed-citation></ref><ref id="r4"><label>4</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Russo</surname><given-names>DP</given-names></name><name><surname>Stoll</surname><given-names>ST</given-names></name><name><surname>Shores</surname><given-names>JH</given-names></name></person-group><article-title>Development of the Attitudes Toward Osteopathic Principles and Practice Scale (ATOPPS): preliminary results.</article-title><source>J Am Osteopath Assoc</source><year>2003</year><volume>103</volume><fpage>429</fpage><lpage>434</lpage><pub-id pub-id-type="pmid">14527078</pub-id></element-citation></ref><ref id="r5"><label>5</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Johnson</surname><given-names>SM</given-names></name><name><surname>Kurtz</surname><given-names>ME</given-names></name><name><surname>Kurtz</surname><given-names>JC</given-names></name></person-group><article-title>Variables influencing the use of osteopathic manipulative treatment in family practice.</article-title><source>J Am Osteopath Assoc</source><year>1997</year><volume>97</volume><fpage>80</fpage><lpage>87</lpage><pub-id pub-id-type="doi">10.7556/jaoa.1997.97.2.80</pub-id><pub-id pub-id-type="pmid">9059002</pub-id></element-citation></ref><ref id="r6"><label>6</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Johnson</surname><given-names>SM</given-names></name><name><surname>Kurtz</surname><given-names>ME</given-names></name></person-group><article-title>Diminished use of osteopathic manipulative treatment and its impact on the uniqueness of the osteopathic profession.</article-title><source>Acad Med</source><year>2001</year><volume>76</volume><fpage>821</fpage><lpage>828</lpage><pub-id pub-id-type="doi">10.1097/00001888-200108000-00016</pub-id><pub-id pub-id-type="pmid">11500286</pub-id></element-citation></ref><ref id="r7"><label>7</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hempstead</surname><given-names>LK</given-names></name><name><surname>Harper</surname><given-names>DM</given-names></name></person-group><article-title>Incorporating osteopathic curriculum into a family medicine residency.</article-title><source>Fam Med</source><year>2015</year><volume>47</volume><fpage>794</fpage><lpage>798</lpage><pub-id pub-id-type="pmid">26545057</pub-id></element-citation></ref><ref id="r8"><label>8</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Draper</surname><given-names>BB</given-names></name><name><surname>Johnson</surname><given-names>JC</given-names></name><name><surname>Fossum</surname><given-names>C</given-names></name><name><surname>Chamberlain</surname><given-names>NR</given-names></name></person-group><article-title>Osteopathic medical students' beliefs about osteopathic manipulative treatment at 4 colleges of osteopathic medicine.</article-title><source>J Am Osteopath Assoc</source><year>2011</year><volume>111</volume><fpage>615</fpage><lpage>630</lpage><pub-id pub-id-type="pmid">22104514</pub-id></element-citation></ref><ref id="r9"><label>9</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hempstead</surname><given-names>LK</given-names></name><name><surname>Rosemergey</surname><given-names>B</given-names></name><name><surname>Foote</surname><given-names>S</given-names></name><name><surname>Swade</surname><given-names>K</given-names></name><name><surname>Williams</surname><given-names>KB</given-names></name></person-group><article-title>Resident and faculty attitudes toward osteopathic-focused education.</article-title><source>J Am Osteopath Assoc</source><year>2018</year><volume>118</volume><fpage>253</fpage><lpage>263</lpage><pub-id pub-id-type="doi">10.7556/jaoa.2018.050</pub-id><pub-id pub-id-type="pmid">29582060</pub-id></element-citation></ref><ref id="r10"><label>10</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Schneider</surname><given-names>CD</given-names></name><name><surname>Meek</surname><given-names>PM</given-names></name><name><surname>Bell</surname><given-names>IR</given-names></name></person-group><article-title>Development and validation of IMAQ: Integrative Medicine Attitude Questionnaire.</article-title><source>BMC Med Educ</source><year>2003</year><volume>3</volume><fpage>5</fpage><pub-id pub-id-type="doi">10.1186/1472-6920-3-5</pub-id><pub-id pub-id-type="pmid">12946276</pub-id></element-citation></ref><ref id="r11"><label>11</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hojat</surname><given-names>M</given-names></name><name><surname>Bianco</surname><given-names>JA</given-names></name><name><surname>Mann</surname><given-names>D</given-names></name><name><surname>Massello</surname><given-names>D</given-names></name><name><surname>Calabrese</surname><given-names>LH</given-names></name></person-group><article-title>Overlap between empathy, teamwork and integrative approach to patient care.</article-title><source>Med Teach</source><year>2015</year><volume>37</volume><fpage>755</fpage><lpage>758</lpage><pub-id pub-id-type="doi">10.3109/0142159X.2014.971722</pub-id><pub-id pub-id-type="pmid">25314019</pub-id></element-citation></ref><ref id="r12"><label>12</label><mixed-citation publication-type="other">Hojat M. Empathy in health professions education and patient care. New York, NY: Springer International; 2016.
</mixed-citation></ref><ref id="r13"><label>13</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hojat</surname><given-names>M</given-names></name><name><surname>DeSantis</surname><given-names>J</given-names></name><name><surname>Shannon</surname><given-names>SC</given-names></name><name><surname>Mortensen</surname><given-names>LH</given-names></name><name><surname>Speicher</surname><given-names>MR</given-names></name><name><surname>Bragan</surname><given-names>L</given-names></name><name><surname>LaNoue</surname><given-names>M</given-names></name><name><surname>Calabrese</surname><given-names>LH</given-names></name></person-group><article-title>The Jefferson Scale of Empathy: a nationwide study of measurement properties, underlying components, latent variable structure, and national norms in medical students.</article-title><source>Adv Health Sci Educ Theory Pract</source><year>2018</year><volume>23</volume><fpage>899</fpage><lpage>920</lpage><pub-id pub-id-type="doi">10.1007/s10459-018-9839-9</pub-id><pub-id pub-id-type="pmid">29968006</pub-id></element-citation></ref><ref id="r14"><label>14</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Colliver</surname><given-names>JA</given-names></name><name><surname>Conlee</surname><given-names>MJ</given-names></name><name><surname>Verhulst</surname><given-names>SJ</given-names></name><name><surname>Dorsey</surname><given-names>JK</given-names></name></person-group><article-title>Rebuttals to critics of studies of the decline of empathy.</article-title><source>Acad Med</source><year>2010</year><volume>85</volume><fpage>1813</fpage><lpage>1814</lpage><pub-id pub-id-type="doi">10.1097/acm.0b013e3181faa3ed</pub-id></element-citation></ref><ref id="r15"><label>15</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sulzer</surname><given-names>SH</given-names></name><name><surname>Feinstein</surname><given-names>NW</given-names></name><name><surname>Wendland</surname><given-names>CL</given-names></name></person-group><article-title>Assessing empathy development in medical education: a systematic review.</article-title><source>Med Educ</source><year>2016</year><volume>50</volume><fpage>300</fpage><lpage>310</lpage><pub-id pub-id-type="doi">10.1111/medu.12806</pub-id><pub-id pub-id-type="pmid">26896015</pub-id></element-citation></ref><ref id="r16"><label>16</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Davis</surname><given-names>MH</given-names></name></person-group><article-title>Measuring individual differences in empathy: Evidence for a multidimensional approach.</article-title><source>J Pers Soc Psychol</source><year>1983</year><volume>44</volume><fpage>113</fpage><lpage>126</lpage><pub-id pub-id-type="doi">10.1037/0022-3514.44.1.113</pub-id></element-citation></ref><ref id="r17"><label>17</label><mixed-citation publication-type="other">Davis MH. Empathy: a social psychological approach. Boulder, Colo.: Westview Press, 1996.
</mixed-citation></ref><ref id="r18"><label>18</label><mixed-citation publication-type="other">Pulos S, Elison J, Lennon R. Hierarchical structure of the interpersonal reactivity index. Social Behavior and Personality: An International Journal. 2004;32(4):355-359. 
</mixed-citation></ref><ref id="r19"><label>19</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hojat</surname><given-names>M</given-names></name><name><surname>Mangione</surname><given-names>S</given-names></name><name><surname>Kane</surname><given-names>GC</given-names></name><name><surname>Gonnella</surname><given-names>JS</given-names></name></person-group><article-title>Relationships between scores of the Jefferson Scale of Physician Empathy (JSPE) and the Interpersonal Reactivity Index (IRI).</article-title><source>Med Teach</source><year>2005</year><volume>27</volume><fpage>625</fpage><lpage>628</lpage><pub-id pub-id-type="doi">10.1080/01421590500069744</pub-id><pub-id pub-id-type="pmid">16332555</pub-id></element-citation></ref><ref id="r20"><label>20</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hojat</surname><given-names>M</given-names></name><name><surname>Ward</surname><given-names>J</given-names></name><name><surname>Spandorfer</surname><given-names>J</given-names></name><name><surname>Arenson</surname><given-names>C</given-names></name><name><surname>Van Winkle</surname><given-names>LJ</given-names></name><name><surname>Williams</surname><given-names>B</given-names></name></person-group><article-title>The Jefferson Scale of Attitudes Toward Interprofessional Collaboration (JeffSATIC): development and multi-institution psychometric data.</article-title><source>J Interprof Care</source><year>2015</year><volume>29</volume><fpage>238</fpage><lpage>244</lpage><pub-id pub-id-type="doi">10.3109/13561820.2014.962129</pub-id><pub-id pub-id-type="pmid">25311270</pub-id></element-citation></ref><ref id="r21"><label>21</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hojat</surname><given-names>M</given-names></name><name><surname>Veloski</surname><given-names>JJ</given-names></name><name><surname>Gonnella</surname><given-names>JS</given-names></name></person-group><article-title>Measurement and correlates of physicians' lifelong learning.</article-title><source>Acad Med</source><year>2009</year><volume>84</volume><fpage>1066</fpage><lpage>1074</lpage><pub-id pub-id-type="doi">10.1097/ACM.0b013e3181acf25f</pub-id><pub-id pub-id-type="pmid">19638773</pub-id></element-citation></ref><ref id="r22"><label>22</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wetzel</surname><given-names>AP</given-names></name><name><surname>Mazmanian</surname><given-names>PE</given-names></name><name><surname>Hojat</surname><given-names>M</given-names></name><name><surname>Kreutzer</surname><given-names>KO</given-names></name><name><surname>Carrico</surname><given-names>RJ</given-names></name><name><surname>Carr</surname><given-names>C</given-names></name><name><surname>Veloski</surname><given-names>J</given-names></name><name><surname>Rafiq</surname><given-names>A</given-names></name></person-group><article-title>Measuring medical students' orientation toward lifelong learning: a psychometric evaluation.</article-title><source>Acad Med</source><year>2010</year><volume>85</volume><fpage>41</fpage><lpage>44</lpage><pub-id pub-id-type="doi">10.1097/ACM.0b013e3181ed1ae9</pub-id><pub-id pub-id-type="pmid">20881701</pub-id></element-citation></ref><ref id="r23"><label>23</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Shirom</surname><given-names>A</given-names></name><name><surname>Melamed</surname><given-names>S</given-names></name></person-group><article-title>A comparison of the construct validity of two burnout measures in two groups of professionals.</article-title><source>International Journal of Stress Management</source><year>2006</year><volume>13</volume><fpage>176</fpage><lpage>200</lpage><pub-id pub-id-type="doi">10.1037/1072-5245.13.2.176</pub-id></element-citation></ref><ref id="r24"><label>24</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Melamed</surname><given-names>S</given-names></name><name><surname>Shirom</surname><given-names>A</given-names></name><name><surname>Toker</surname><given-names>S</given-names></name><name><surname>Berliner</surname><given-names>S</given-names></name><name><surname>Shapira</surname><given-names>I</given-names></name></person-group><article-title>Burnout and risk of cardiovascular disease: evidence, possible causal paths, and promising research directions.</article-title><source>Psychol Bull</source><year>2006</year><volume>132</volume><fpage>327</fpage><lpage>353</lpage><pub-id pub-id-type="doi">10.1037/0033-2909.132.3.327</pub-id><pub-id pub-id-type="pmid">16719565</pub-id></element-citation></ref><ref id="r25"><label>25</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gerber</surname><given-names>M</given-names></name><name><surname>Colledge</surname><given-names>F</given-names></name><name><surname>M&#xFC;cke</surname><given-names>M</given-names></name><name><surname>Schilling</surname><given-names>R</given-names></name><name><surname>Brand</surname><given-names>S</given-names></name><name><surname>Ludyga</surname><given-names>S</given-names></name></person-group><article-title>Psychometric properties of the Shirom-Melamed Burnout Measure (SMBM) among adolescents: results from three cross-sectional studies.</article-title><source>BMC Psychiatry</source><year>2018</year><volume>18</volume><fpage>266</fpage><pub-id pub-id-type="doi">10.1186/s12888-018-1841-5</pub-id><pub-id pub-id-type="pmid">30144799</pub-id></element-citation></ref><ref id="r26"><label>26</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mangione</surname><given-names>S</given-names></name><name><surname>Chakraborti</surname><given-names>C</given-names></name><name><surname>Staltari</surname><given-names>G</given-names></name><name><surname>Harrison</surname><given-names>R</given-names></name><name><surname>Tunkel</surname><given-names>AR</given-names></name><name><surname>Liou</surname><given-names>KT</given-names></name><name><surname>Cerceo</surname><given-names>E</given-names></name><name><surname>Voeller</surname><given-names>M</given-names></name><name><surname>Bedwell</surname><given-names>WL</given-names></name><name><surname>Fletcher</surname><given-names>K</given-names></name><name><surname>Kahn</surname><given-names>MJ</given-names></name></person-group><article-title>Medical Students' Exposure to the Humanities Correlates with Positive Personal Qualities and Reduced Burnout: A Multi-Institutional U.S. Survey.</article-title><source>J Gen Intern Med</source><year>2018</year><volume>33</volume><fpage>628</fpage><lpage>634</lpage><pub-id pub-id-type="doi">10.1007/s11606-017-4275-8</pub-id><pub-id pub-id-type="pmid">29380213</pub-id></element-citation></ref><ref id="r27"><label>27</label><mixed-citation publication-type="other">Zuckerman M. Zuckerman-Kuhlman Personality Questionnaire (ZKPQ): An alternative five-factor model. In: DeRaad B, Perugini M, editors. Big five assessment. Seattle, WA: Hogrefe &amp; Huber; 2002.
</mixed-citation></ref><ref id="r28"><label>28</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hojat</surname><given-names>M</given-names></name><name><surname>Zuckerman</surname><given-names>M</given-names></name><name><surname>Magee</surname><given-names>M</given-names></name><name><surname>Mangione</surname><given-names>S</given-names></name><name><surname>Nasca</surname><given-names>T</given-names></name><name><surname>Vergare</surname><given-names>M</given-names></name><name><surname>Gonnella</surname><given-names>JS</given-names></name></person-group><article-title>Empathy in medical students as related to specialty interest, personality, and perceptions of mother and father.</article-title><source>Personality and Individual Differences</source><year>2005</year><volume>39</volume><fpage>1205</fpage><lpage>1215</lpage><pub-id pub-id-type="doi">10.1016/j.paid.2005.04.007</pub-id></element-citation></ref><ref id="r29"><label>29</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hojat</surname><given-names>M</given-names></name><name><surname>Shannon</surname><given-names>SC</given-names></name><name><surname>DeSantis</surname><given-names>J</given-names></name><name><surname>Speicher</surname><given-names>MR</given-names></name><name><surname>Bragan</surname><given-names>L</given-names></name><name><surname>Calabrese</surname><given-names>LH</given-names></name></person-group><article-title>Empathy in medicine national norms for the Jefferson Scale of Empathy: a nationwide project in osteopathic medical education and empathy (POMEE).</article-title><source>J Am Osteopath Assoc</source><year>2019</year><volume>119</volume><fpage>520</fpage><lpage>532</lpage><pub-id pub-id-type="doi">10.7556/jaoa.2019.091</pub-id><pub-id pub-id-type="pmid">31355891</pub-id></element-citation></ref><ref id="r30"><label>30</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hojat</surname><given-names>M</given-names></name><name><surname>Shannon</surname><given-names>SC</given-names></name><name><surname>DeSantis</surname><given-names>J</given-names></name><name><surname>Speicher</surname><given-names>MR</given-names></name><name><surname>Bragan</surname><given-names>L</given-names></name><name><surname>Calabrese</surname><given-names>LH</given-names></name></person-group><article-title>Does empathy decline in the clinical phase of medical education? A nationwide, multi-institutional, cross-sectional study of students at DO-granting medical schools.</article-title><source>Acad Med</source><year>2020</year><volume>95</volume><fpage>911</fpage><lpage>918</lpage><pub-id pub-id-type="doi">10.1097/ACM.0000000000003175</pub-id><pub-id pub-id-type="pmid">31977341</pub-id></element-citation></ref><ref id="r31"><label>31</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hojat</surname><given-names>M</given-names></name><name><surname>DeSantis</surname><given-names>J</given-names></name><name><surname>Shannon</surname><given-names>SC</given-names></name><name><surname>Speicher</surname><given-names>MR</given-names></name><name><surname>Bragan</surname><given-names>L</given-names></name><name><surname>Calabrese</surname><given-names>LH</given-names></name></person-group><article-title>Empathy as related to gender, age, race and ethnicity, academic background and career interest: a nationwide study of osteopathic medical students in the United States.</article-title><source>Med Educ</source><year>2020</year><volume>54</volume><fpage>571</fpage><lpage>581</lpage><pub-id pub-id-type="doi">10.1111/medu.14138</pub-id><pub-id pub-id-type="pmid">32083747</pub-id></element-citation></ref><ref id="r32"><label>32</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hojat</surname><given-names>M</given-names></name><name><surname>Xu</surname><given-names>G</given-names></name></person-group><article-title>A visitor's guide to effect sizes: statistical significance versus practical (clinical) importance of research findings.</article-title><source>Adv Health Sci Educ Theory Pract</source><year>2004</year><volume>9</volume><fpage>241</fpage><lpage>249</lpage><pub-id pub-id-type="doi">10.1023/B:AHSE.0000038173.00909.f6</pub-id><pub-id pub-id-type="pmid">15316274</pub-id></element-citation></ref><ref id="r33"><label>33</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hojat</surname><given-names>M</given-names></name><name><surname>Gonnella</surname><given-names>JS</given-names></name><name><surname>Nasca</surname><given-names>TJ</given-names></name><name><surname>Mangione</surname><given-names>S</given-names></name><name><surname>Veloksi</surname><given-names>JJ</given-names></name><name><surname>Magee</surname><given-names>M</given-names></name></person-group><article-title>The Jefferson Scale of Physician Empathy: further psychometric data and differences by gender and specialty at item level.</article-title><source>Acad Med</source><year>2002</year><volume>77</volume><fpage>58</fpage><lpage>60</lpage><pub-id pub-id-type="doi">10.1097/00001888-200210001-00019</pub-id><pub-id pub-id-type="pmid">12377706</pub-id></element-citation></ref><ref id="r34"><label>34</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hojat</surname><given-names>M</given-names></name><name><surname>Gonnella</surname><given-names>JS</given-names></name></person-group><article-title>Eleven years of data on the Jefferson Scale of Empathy-Medical Student Version (JSE-S): proxy norm data and tentative cutoff scores.</article-title><source>Med Princ Pract</source><year>2015</year><volume>24</volume><fpage>344</fpage><lpage>350</lpage><pub-id pub-id-type="doi">10.1159/000381954</pub-id><pub-id pub-id-type="pmid">25924560</pub-id></element-citation></ref><ref id="r35"><label>35</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hojat</surname><given-names>M</given-names></name><name><surname>Vergare</surname><given-names>M</given-names></name><name><surname>Isenberg</surname><given-names>G</given-names></name><name><surname>Cohen</surname><given-names>M</given-names></name><name><surname>Spandorfer</surname><given-names>J</given-names></name></person-group><article-title>Underlying construct of empathy, optimism, and burnout in medical students.</article-title><source>Int J Med Educ</source><year>2015</year><volume>6</volume><fpage>12</fpage><lpage>16</lpage><pub-id pub-id-type="doi">10.5116/ijme.54c3.60cd</pub-id><pub-id pub-id-type="pmid">25633650</pub-id></element-citation></ref></ref-list>
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